RedHill Biopharma announces positive results of COVID-19 opaganib study

By Nikita Chaurasia  Date: 2021-01-05

RedHill Biopharma announces positive results of COVID-19 opaganib study

Israeli specialty biopharmaceutical company, RedHill Biopharma Ltd., has announced the preliminary data from the phase-2 clinical trials of its drug opaganib which was administered orally in patients suffering from COVID-19. The trial round included around 40 participants, with the study showing positive signals of efficacy and safety.

For the uninitiated, opaganib is an oral drug that acts as a sphingosine kinase-2 (SK2) inhibitor and is used for treating individuals with COVID-19 pneumonia. Its primary function is to target the host cell responsible for viral replication, thereby potentially minimizing the likelihood of viral resistance.

It is also worth mentioning that RedHill’s opaganib has received orphan drug designation by the U.S. Food & Drug Administration (FDA) for treating cholangiocarcinoma. The drug is currently being evaluated in a phase-2 study for the treatment of prostate cancer as well as cholangiocarcinoma.

If reports are to be believed, the preliminary data comes from a randomized, placebo-controlled, double-blind clinical trial round conducted on COVID-19 patients that required oxygen support. Furthermore, the trials found that there were no material safety differences between opaganib and the placebo treatment arms.

The drug reportedly demonstrated consistent progressive improvement in reducing oxygen requirements of the patients by the 14th day of the trial. Specifically, 52.6% of the patients in the opaganib group no longer required oxygen support as compared to 22.2% in the placebo group.

Medical director of RedHill Biopharma, Mark L. Levitt, was quoted saying that the organization expects the preliminary results from the recently conducted COVID-19 therapy study to support its global phase 2/3 study. The company will compile a robust data set for supporting the potential filing of emergency use applications, he added.

About RedHill Biopharma Ltd.

Since its inception in 2009, Redhill Biopharma primarily focuses on the treatment of gastrointestinal and other infectious diseases. The company’s products are based on several technology platforms and are known to be more affordable than other chemical entities under development.

Source credits –

https://www.prnewswire.com/news-releases/redhill-biopharma-annonce-les-resultats-positifs-de-la-phase-2-de-l-etude-covid-19-sur-l-opaganib-en-termes-de-securite-et-d-efficacite-845306278.html

About Author

Nikita Chaurasia     aeresearch.net

Nikita Chaurasia

An accomplished professional in the field of content development, playing with words comes naturally to Nikita Chaurasia. After completing her post-graduate MBA degree in Advertising and PR, Nikita worked across numerous content-driven verticals, undertaking diverse r...

Read More

More News By Nikita Chaurasia

1health to offer two types of COVID-19 testing kits to SkyWest Airlines

1health to offer two types of COVID-19 testing kits to SkyWest Airlines

By Nikita Chaurasia

Leading Testing as a Service (TaaS) provider, 1health, recently announced that it has partnered with SkyWest Airlines, a SkyWest Inc. subsidiary, to provide two types of COVID-19 tests to the airline’s personnel. Mehdi Maghsoodnia, CEO at 1hea...

FBI to remove backdoors from hacked Microsoft Exchange email servers

FBI to remove backdoors from hacked Microsoft Exchange email servers

By Nikita Chaurasia

Following the recent cyber-attack in the US, a court in Houston has reportedly authorized a new FBI operation to copy and eliminate backdoors from large number of Microsoft Exchange email servers across the country. During this hacking event, the hac...

France might ban short domestic flights to reduce its carbon footprint

France might ban short domestic flights to reduce its carbon footprint

By Nikita Chaurasia

French lawmakers recently came to a unanimous decision to ban domestic flights for distances that can be covered by train in over two-and-a-half- hours. The country aims to impose these restrictions in an effort to reduce carbon emissions, even as th...

Kavak secures USD 485 million in funding, eyes Latin America expansion

Kavak secures USD 485 million in funding, eyes Latin America expansion

By Nikita Chaurasia

Kavak, a Mexico-based used-car platform, has reportedly reached a valuation of USD 4 billion after securing USD 485 million during a new funding round. This makes it the fastest-growing as well as the most valued company in Latin America. The latest...

Zydus seeks DCGI approval for PegIFN drug to treat COVID-19 patients

Zydus seeks DCGI approval for PegIFN drug to treat COVID-19 patients

By Nikita Chaurasia

Indian pharmaceutical company Zydus Cadila is reportedly seeking approval from DCGI (Drug Controller General of India) for its PegIFN (Pegylated Interferon Alpha-2b), a hepatitis C drug, to treat COVID-19 patients, after its third phase of clinical t...